The K-Means algorithms typically utilize Euclidean distance to calculate the similarity between data points when dealing with large-scale heterogeneous data. However， this method has problems of low efficiency and high computational complexity. Inspired by the significant advantage of Hamming distance in handling data similarity calculation， a Quantum K-Means Hamming （QKMH） algorithm was proposed to calculate similarity. First， the data was prepared and made into quantum state， and the quantum Hamming distance was used to calculate similarity between the points to be clustered and the K cluster centers. Then， the Grover’s minimum search algorithm was improved to find the cluster center closest to the points to be clustered. Finally， these steps were repeated until the designated number of iterations was reached or the clustering centers no longer changed. Based on the quantum simulation computing framework QisKit， the proposed algorithm was validated on the MNIST handwritten digit dataset and compared with various traditional and improved methods. Experimental results show that the F1 score of the QKMH algorithm is improved by 10 percentage points compared with that of the Manhattan distance-based quantum K-Means algorithm and by 4.6 percentage points compared with that of the latest optimized Euclidean distance-based quantum K-Means algorithm， and the time complexity of the QKMH algorithm is lower than those of the above comparison algorithms.